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. 2016 Mar 1;131:753–773. doi: 10.1007/s00401-016-1551-3

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 1 — Ang-2 increases brain endothelial permeability in vitro. a MBMECs from WT and Ang-2 GOF brains were seeded on transwell inserts and transferred to a cellZscope^® system to obtain continuous TEER values. The inset shows a transwell insert along with top and bottom electrodes typical of a cellZscope^® device. The graph shows a representative experiment that indicates reduced TEER values in Ang-2 GOF MBMECs compared to WT that is sustained up to 48 h post-seeding when the monolayers reach confluency. b GOF MBMECs showed lower TEER than control cells at 24 and 48 h. c WT-MBMECs treated with hAng-2 resulted in reduced TEER. d hAng-2 treatment resulted in increased tracer flux across MBMECs (b–d, n = 3)