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. 2016 Mar 1;131:753–773. doi: 10.1007/s00401-016-1551-3

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 4 — Ultrastructural analysis of Ang-2 GOF mice. a EM revealed swollen astrocytic endfeet, degenerating pericytes and more vesicles and gaps (arrows) between ECs in GOF. AEF astrocytic endfeet, BL basal lamina, PC pericyte (scale bar sizes are indicated in the images). b The pericyte coverage analyzed from EM images is decreased in Ang-2 GOF mice (100 vessels were analyzed; n = 5). c Increased pericyte degeneration was observed in Ang-2 GOF mice (100 vessels analyzed; n = 5). d The gaps within EC junction increased in Ang-2 GOF mice (100 vessels analyzed; n = 5). e The number of cortical vesicles of ECs in Ang-2 GOF mice increased (20 vessels of similar size 4–5 µm lumen per mouse were analyzed; n = 3)