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. 2016 Mar 1;131:753–773. doi: 10.1007/s00401-016-1551-3

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© The Author(s) 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 8 — Effects of AKB-9785 treatment in vitro. a MBMECs pre-treated with hAng-2 increased Tie2/Akt activation upon AKB-9785 treatment (n = 3). b bEnd5 Western blots revealed Tie2/Akt activation, but a decrease (non-significant) in pVE-cadherin by AKB-9785 (n = 3). c MBMECs pre-treated with recombinant hAng-2 [500 ng/ml] followed by AKB-9785 [1 µM] treatment revealed increased TEER values. d The in vitro permeability tracer experiment with a 3 kD Texas Red-dextran showed a decrease in permeability with AKB-9785 + hAng-2 compared to hAng-2 treatment alone. This difference was not detected in the presence of filipin. e The phosphorylation of Akt in Western Blot analysis could only be identified in MBMECs, but not pericytes (n = 3)