Table 3.
Mucosal-associated invariant T cells in the diseases
| Category | Mouse strains | Disease model | Phenotype | Ref. |
| Bacterial infection | MR1-/- Vα19 iTCR Tg Vβ6 Vβ8 Tg | Escherichia coli Micobacterium abcessus | Increase in the bacterial burden Repression of the bacterial burden | [16] |
| MR1-/- | Klebsiella pneumoniae | Increased susceptibility to K. pneumoniae infection | [36] | |
| MR1-/- | Mycobacterium bovis BCG | Enhanced bacterial growth at the early stage of infection | [35] | |
| Francisella tularensis | Delayed adaptive immune reaction | [34] | ||
| Autoimmune diseases | Vα19 iTCR Tg | Experimental autoimmune encephalomyelitis (model of MS) | Suppressed disease induction and progression | [78] |
| MR1-/- | Collagen-induced arthritis (model of rheumatoid arthritis) | Improved CIA score | [86] | |
| Adoptive transfer Jα33+ MAIT cells into BALB/c | TNBS induced colitis | Improved disease index | [105] | |
| B10.RIII | Spondyloarthropathy by IL-23 | Enthesitis induced by IL-22 produced from IL-23R+RORγt+CD4-CD8- T cells (MAIT cells?) in the entheses | [91] | |
| Others | Vα19 iTCR Tg NOD | Non-obese diabetes | Delayed disease onset | [106] |
| Vα19 iTCR Tg | Delayed-type hypersensitivity to sheep erythrocytes (type IV allergy) | Suppression of the disease | [106] |
MAIT: Mucosal-associated invariant T; IL: Interleukin; CIA: Collagen-induced arthritis; iTCR: Invariant T cell receptor.