Table 1.
MRB1 complex subunits
| Subcomplex | Name | Alias | Domains | TriTrypDB # | References* |
|---|---|---|---|---|---|
| Core | GAP1 | GRBC2 | Tb927.2.3800 | 48,51-54,60,61 | |
| Core | GAP2 | GRBC1 | Tb927.7.2570 | 48,51-54,60,61 | |
| Core | MRB3010 | GRBC6 | RPS2 | Tb927.5.3010 | 48,50,52,59,68,71 |
| Core | MRB5390 | GRBC4 | Tb11.02.5390 | 48,52,58 | |
| Core | MRB8620 | GRBC3 | Tb927.11.16860 | 48,52,70 | |
| Core | MRB11870 | GRBC5 | pentein | Tb927.10.11870 | 48,52,71 |
| Core | MRB0880 | GRBC7 | Tb927.11.9140 | 48,52 | |
| Core** | RBP30 | none | RRM | Tb927.5.2100 | na |
| Core** | none | none | Tb927.9.1420 | na | |
| Core** | none | none | Tb927.10.10120 | na | |
| TbRGG2 | TbRGG2 | none | RRM, RGG | Tb927.10.10830 | 48,49,52,58,63,74 |
| TbRGG2 | MRB1860 | REMC2 | Tb927.2.1860 | 48,52 | |
| TbRGG2 | MRB4160§ | REMC5 | Tb927.4.4160 | 48,52,69 | |
| TbRGG2 | MRB800 | REMC3 | Tb927.7.800 | 48,52 | |
| TbRGG2 | MRB8170§ | REMC5A | Tb927.8.8170 | 48,52,69 | |
| TbRGG2 | MRB8180¶ | REMC4 | Tb927.8.8180 | 48,52 | |
| TbRGG2 | PhyH | none | PhyH | Tb927.9.7260 | na |
| Unknown | MRB10130 | REMC1 | ARM/HEAT | Tb927.10.10130 | 48,52,53 |
*
Listed are publications in which a given protein was either analyzed by RNAi-silencing, used as bait in a protein-protein interaction study, or in which recombinant protein was characterized.
**
Designated as core components in Reference 48, but not found in any other MRB1 purifications.
§
MRB4160 and MRB8170 are paralogues arising from a gene duplication that share ~85% amino acid identity.
¶
MRB8180 is paralogous with Tb927.4.4150. These paralogues share ~99% amino acid identity, and thus are designated as a single protein here.