Table 1.

Source of data in the model from the systematic review

Author	Patients	Treatment	Adherence definition	Endpoint	Extracted data
Probability of adherence
Patel et al. [11]	Adults taking a CCB or statin (but not both) who then initiated treatment with SPAA or added CCB to statin (or vice versa)	Co-administration vs. single-pill administration	PDC ≥80%	% of patients with PDC ≥ 80 %	ATR/AML: 67.7% ATR+AML: 49.9%
Chapman et al. [15]	Patients with co-morbid hypertension and dyslipidemia at high risk for cardiovascular disease	Co-administration vs. single-pill administration	PDC ≥80%	% of adherent patient	Diabetes adherence OR (vs. noncoronary artery disease) Adjusted OR (95% CI): 1.06 (0.96. 1.17) Unadjusted OR (95% CI): 0.99 (0.90 1.08)
LDL-C level according to adherence level
Parris et al. [16]	Patients with diabetes and dyslipidemia	Statin	PDC ≥80%	LDL-C goal (<100 mg/ dL) attainment according to adherence level	PDC≥80% (MPR, %): 56-78 PDC < 80% (MPR. %): 16-42

CCB, calcium channel blocker; SPAA, single-pill amlodipine/atorvastatin; PDC, proportion of days covered; ATR, atorvastatin; AML, amlodipine; OR, odds ratio; CI, confidence interval; LDL-C, low density lipoprotein cholesterol; MPR, medication possession ratio.