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. 2016 Apr 19;6:24675. doi: 10.1038/srep24675

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Copyright © 2016, Macmillan Publishers Limited

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(a) Dose-response curves for HTOXAR3 cell line, after CXCL8 and (b) CXCL1 gene silencing, treated with 0-100 μM OXA for 24 hours (mean ± SEM). Insets show siRNA-mediated gene silencing efficiency at 48 h post-transfection. IC50 values are indicated as mean (95% CI). (c) Representative western blot images showing changes in phosphorylated IκBα (p-IκBα Ser32/36), phosphorylated Akt (p-Akt Ser473), Survivin, Bcl-2 and Cyclin D1 protein expression in HTOXAR3 cells under control (siNTC) and CXCL8 (siCXCL8) or (d) CXCL1 (siCXCL1) gene silencing. All results were obtained from at least 3 independent experiments.