Table 3.
Measures of cardiovascular structure and function at Visit 5 by the percent CVHS attained between Visits 1 and 5.
| N | Category of percent CVHS attained | Adj P value | |||||
|---|---|---|---|---|---|---|---|
| <50% N=612 | 50-60% N=945 | 60-70% N=1,303 | 70-80% N=742 | ≥80% N=696 | |||
| LV Structure | |||||||
| LVEDV (ml) | 3,999 | 83.3 [81.8,84.9] | 80.7 [79.5,81.9] | 79.5 [78.5,80.5] | 77.2 [75.8,78.5] | 77.1 [75.7,78.5] | <0.001 |
| LV MWT (cm) | 4,088 | 1.03 [1.02,1.04] | 1.00 [0.99,1.01] | 0.97 [0.96,0.98] | 0.94 [0.93,0.95] | 0.92 [0.91,0.93] | <0.001 |
| LV mass (g) | 4,078 | 160 [157,163] | 150 [147,152] | 142 [140,143] | 132 [129,134] | 126 [123,128] | <0.001 |
| LVH (%) | 4,078 | 13.9 [11.6,16.2] | 10.1 [8.3,11.8] | 7.2 [5.8,8.7] | 5.7 [3.7,7.6] | 3.0 [1.0,5.0] | <0.001 |
| LV Systolic Function | |||||||
| LVEF (%) | 4,107 | 66 [65.5,66.4] | 66.2 [65.9,66.6] | 66.0 [65.7,66.3] | 66.2 [65.8,66.6] | 66.2 [65.8,66.6] | 0.68 |
| Longitudinal strain (%) | 3,867 | −18.0 [−18.2,−17.8] | −18.2 [−18.3,−18] | −18.2 [−18.4,−18.1] | −18.5 [−18.6,−18.3] | −18.7 [−18.8,−18.5] | <0.001 |
| LV Diastolic Function | |||||||
| TDI e' (cm/s) | 4,100 | 5.49 [5.37,5.61] | 5.64 [5.55,5.73] | 5.66 [5.59,5.74] | 5.85 [5.75,5.96] | 6.07 [5.97,6.18] | <0.001 |
| E/e' ratio | 4,095 | 13.0 [12.7,13.3] | 12.6 [12.4,12.9] | 11.8 [11.6,12] | 11.5 [11.2,11.7] | 10.9 [10.6,11.2] | <0.001 |
| LA volume (ml) | 4,073 | 50.0 [48.8,51.2] | 47.3 [46.3,48.2] | 45.3 [44.5,46.1] | 42.8 [41.7,43.8] | 42.2 [41.2,43.3] | <0.001 |
| RV Function & Pulmonary Pressure | |||||||
| RVFAC (%) | 3,782 | 52.5 [51.9,53.2] | 52.3 [51.7,52.8] | 52.4 [51.9,52.8] | 53.2 [52.6,53.7] | 54 [53.4,54.5] | <0.001 |
| TR velocity (m/s) | 2,345 | 2.46 [2.43,2.49] | 2.41 [2.38,2.43] | 2.36 [2.34,2.38] | 2.33 [2.3,2.35] | 2.31 [2.29,2.34] | <0.001 |
| Arterial Structure & Function | |||||||
| Aortic root diameter (cm) | 4,092 | 3.24 [3.21,3.27] | 3.22 [3.2,3.24] | 3.17 [3.16,3.19] | 3.14 [3.11,3.16] | 3.14 [3.11,3.16] | <0.001 |
| Ea (mmHg/ml) | 4,076 | 1.80 [1.76,1.84] | 1.79 [1.76,1.82] | 1.85 [1.82,1.87] | 1.90 [1.86,1.93] | 1.83 [1.80,1.87] | 0.002 |
| MAP (mmHg) | 4,287 | 90 [89,91] | 89 [88,89] | 89 [88,89] | 88 [88,89] | 86 [85,86] | <0.001 |
| PWV (cm/s) | 3,401 | 1265 [1228,1302] | 1199 [1171,1226] | 1151 [1129,1173] | 1132 [1103,1161] | 1100 [1070,1129] | <0.001 |
| Biomarkers of Myocardial Stress & Injury | |||||||
| NT-proBNP (ng/l) | 4,128 | 136 [124,148] | 120 [111,128] | 117 [110,124] | 109 [100,119] | 111 [99,122] | <0.001 |
| hsTn-T (ng/l) | 4,246 | 12.2 [11.6,12.8] | 10.7 [10.3,11.1] | 9.7 [9.4,10.0] | 8.7 [8.3, 9.2] | 9.0 [8.5, 9.6] | <0.001 |
Values are adjusted for age, gender, race, and field center. P value is P for trend. Values are multivariable adjusted means and 95% confidence intervals. Percent CVHS attained was calculated as the sum of the CVHS at Visits 1 through 5 divided by the maximum number of possible points.