Table 4.
Measures of cardiovascular structure and function at Visit 5 by category of slope of change in CVHS per decade from Visit 1 through Visit 5.
| Slope of Change in CVHS per decade of follow-up |
Adj P for trend | |||||
|---|---|---|---|---|---|---|
| >1 point /decade decrease N=583 | 0.5 – 1 point/decade decrease N=1,139 | 0 – 0.5 point/decade decrease N=1,446 | 0 – 0.5 point/decade increase N=922 | ≥0.5 point/decade increase N=208 | ||
| LV Structure | ||||||
| LVEDV (ml) | 79.3 [77.6,80.9] | 79.2 [78.0,80.3] | 79.7 [78.7,80.6] | 79.7 [78.5,81.0] | 78.4 [75.8,81.0] | 0.85 |
| LV MWT (cm) | 1.00 [0.99,1.01] | 0.98 [0.97,0.99] | 0.97 [0.96,0.97] | 0.95 [0.94,0.96] | 0.93 [0.91,0.94] | <0.001 |
| LV mass (g) | 151 [147,154] | 144 [142,146] | 141 [140,143] | 135 [133,138] | 129 [124,133] | <0.001 |
| LVH (%) | 9.2 [6.8,11.6] | 8.7 [7.1,10.3] | 8.4 [7.0,9.8] | 5.2 [3.4,7.0] | 5.7 [1.9,9.5] | 0.008 |
| LV Systolic Function | ||||||
| LVEF (%) | 66.1 [65.6,66.6] | 66.2 [65.9,66.6] | 66.0 [65.7,66.3] | 66.2 [65.8,66.5] | 66.2 [65.5,67] | 0.94 |
| Longitudinal strain (%) | −18.1 [−18.4,−17.9] | −18.2 [−18.3,−18.1] | −18.3 [−18.4,−18.1] | −18.5 [−18.7,−18.3] | −18.8 [−19.2,−18.5] | <0.001 |
| LV Diastolic Function | ||||||
| TDI e' (cm/s) | 5.5 [5.4,5.7] | 5.6 [5.5,5.7] | 5.8 [5.7,5.9] | 5.9 [5.8,6.0] | 5.9 [5.7,6.1] | <0.001 |
| E/e' ratio | 12.3 [11.9,12.6] | 12.2 [12.0,12.4] | 11.9 [11.7,12.1] | 11.6 [11.3,11.8] | 11.5 [11.0,12] | <0.001 |
| LA volume (ml) | 46.2 [44.9,47.5] | 45.9 [45.1,46.8] | 45.1 [44.3,45.8] | 45.1 [44.2,46.1] | 43.8 [41.7,45.8] | 0.04 |
| RV Function & Pulmonary Pressure | ||||||
| RVFAC (%) | 52.3 [51.7,53] | 52.6 [52.2,53.1] | 52.8 [52.4,53.2] | 53.2 [52.7,53.7] | 52.9 [51.8,54] | 0.09 |
| TR velocity (m/s) | 2.41 [2.38,2.44] | 2.4 [2.37,2.42] | 2.36 [2.34,2.37] | 2.35 [2.32,2.37] | 2.24 [2.19,2.29] | <0.001 |
| Arterial Structure & Function | ||||||
| Aortic root diameter (cm) | 3.21 [3.18-3.24] | 3.18 [3.16-3.20] | 3.17 [3.16-3.19] | 3.16 [3.14-3.18] | 3.20 [3.15-3.24] | 0.09 |
| Ea (mmHg/ml) | 1.85 [1.81,1.89] | 1.82 [1.79,1.85] | 1.86 [1.83,1.88] | 1.82 [1.79,1.85] | 1.81 [1.74,1.87] | 0.53 |
| MAP (mmHg) | 91 [90,92] | 89 [88,89] | 88 [88,89] | 87 [86,88] | 85 [84,87] | <0.001 |
| PWV (cm/s) | 1193 [1154,1230] | 1161 [1136,1186] | 1156 [1135,1177] | 1167 [1139,1194] | 1099 [1043,1156] | 0.11 |
| Biomarkers of Myocardial Stress & Injury | ||||||
| NT-proBNP (ng/l) | 118 [107,130] | 117 [110,125] | 112 [105,118] | 122 [114,131] | 137 [119,154] | 0.26 |
| hsTn-T (ng/l) | 10.3 [9.8-10.9] | 10.0 [9.6,10.4] | 10.1 [9.8,10.4] | 9.7 [9.3,10.1] | 8.9 [8.0, 9.8] | <0.001 |
Values are adjusted for CVHS at Visit 1, age, gender, race, and field center. P value is P for trend. Values are multivariable adjusted means and 95% confidence intervals.