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. 2016 Apr 18;16:274. doi: 10.1186/s12885-016-2302-5

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© Brodsky et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Association of colXα1 expression with NAC response. a Box plot of the Col10A1 probeset on the Affymetrix HTA 2.0 microarray distinguishes good and poor responding ER+/HER2+ breast tumors. The one outlier on the array, has an intermediate colXα1 IHC score of 1. b Gene Set Enrichment Analysis reveals enrichment of the Gene Ontology (GO) category, collagens, in pCR resistant ER+/HER2+ breast tumors. Each black line represents one gene in the GO collagen gene set. c Heat map of mRNA expression changes for all measured collagens on the microarray. d qPCR of Col10A1 mRNA expression correlates with the microarray data