Table 2.
Results of KEGG (Kyoto encyclopedia of genes and genomes) and reactome pathway enrichment analysis of differentially expressed genes in acute respiratory distress syndrome ARDS (top 12 listed)
| ID | Term | Count | P value | ||
|---|---|---|---|---|---|
| KEGG | Up-regulate | 04110 | Cell cycle | 5 | 0.0035 |
| 04640 | Hematopoietic cell lineage | 4 | 0.006 | ||
| 04114 | Oocyte meiosis | 4 | 0.0138 | ||
| Down-regulate | 04145 | Phagosome | 4 | 0.0031 | |
| 04623 | Cytosolic DNA-sensing pathway | 2 | 0.0216 | ||
| 04640 | Hematopoietic cell lineage | 2 | 0.0496 | ||
| Reactome | Up-regulate | 68877 | Mitotic prometaphase | 8 | 4.95E−06 |
| 69278 | Cell cycle, mitotic | 15 | 6.51E−06 | ||
| 2500257 | Resolution of sister chromatid cohesion | 7 | 2.81E−05 | ||
| Down-regulate | 3296197 | Hydroxycarboxylic acid-binding receptors | 2 | 6.93E−05 | |
| 168249 | Innate immune system | 10 | 0.0003 | ||
| 168256 | Immune system | 12 | 0.0011 |
P value <0.05 was considered as threshold values of significant difference