Table 3.
Top 20 genes that evaluated by subgraph centrality, betweenness centrality and degree centrality respectively in the protein–protein interaction (PPI) network
| Gene name | Subgraph centrality | Gene name | Betweenness centrality | Gene name | Degree centrality |
|---|---|---|---|---|---|
| CCNB2 | 92,020.02 | TOP2A | 4238.0317 | TOP2A | 29 |
| CCNB1 | 91,113.23 | HMMR | 2151.6792 | CCNB1 | 26 |
| TOP2A | 86,794.31 | CCNB1 | 2114.8433 | CCNB2 | 24 |
| BUB1 | 85,489.84 | VCAN | 1703.794 | BUB1 | 20 |
| KIF11 | 72,242.97 | BIRC5 | 1687.0967 | BIRC5 | 20 |
| BIRC5 | 65,156.9 | TFRC | 1503.5779 | KIF11 | 18 |
| CENPF | 57,783.895 | LRRK2 | 1472.6691 | CENPF | 15 |
| NUSAP1 | 57,466.84 | TYMS | 977.0087 | NUSAP1 | 15 |
| DLGAP5 | 53,906.652 | SPTA1 | 971.715 | DLGAP5 | 15 |
| NUF2 | 47,763.83 | FLT3 | 961.2316 | NUF2 | 13 |
| PRC1 | 46,547.062 | MPP7 | 923.03656 | PRC1 | 13 |
| NCAPG | 43,847.594 | MME | 917.51965 | NCAPG | 13 |
| CKS2 | 37,598.816 | PNP | 807.13245 | RRM2 | 13 |
| CEP55 | 34,042.55 | TFPI | 783.21027 | CKS2 | 12 |
| RRM2 | 32,993.395 | RAD23A | 767.7287 | CEP55 | 11 |
| TPX2 | 23,101.832 | TUBB1 | 708.9906 | TPX2 | 9 |
| TYMS | 18,167.875 | MMP8 | 698.92865 | TYMS | 9 |
| CDKN3 | 14,048.942 | CCNB2 | 688.69775 | TFRC | 9 |
| KIF14 | 11,749.522 | DDB1 | 606.85 | CDKN3 | 8 |
| ASPM | 11,499.243 | LTF | 585.95557 | ASPM | 8 |
Combined score >0.4 was considered as threshold values of significant difference