Table 2.

Tubular effects of the AT1R antagonist ZD 7155 in conscious lambs

Variable	One week			Six weeks
	Control	30 min	60 min	Control	30 min	60 min
CNa (μL · g−1 · min−1)	0.24 ± 0.05	0.18 ± 0.08	0.21 ± 0.16	0.90 ± 0.52**	0.94 ± 0.42**	0.62 ± 0.29**,*
FRNa %	99.93 ± 0.03	99.90 ± 0.08	99.73 ± 0.60	99.90 ± 0.12	99.84 ± 0.23	99.89 ± 0.12
PRNa %	78.3 ± 8.8	81.8 ± 9.1	84.1 ± 10.8	70.4 ± 19.1**	69.4 ± 21.1**	70.1 ± 15.6**
DRNa %	21.7 ± 8.8	18.1 ± 9.1	15.6 ± 10.6	29.5 ± 19.1**	30.6 ± 21.6**	29.8 ± 15.6**
CK (mL · g−1 · min−1)	0.18 ± 0.10	0.09 ± 0.08	0.09 ± 0.07	0.64 ± 0.34**	0.45 ± 0.16**	0.39 ± 0.16**
FRK %	59.2 ± 17.1	66.0 ± 16.3	64.3 ± 23.7	56.7 ± 18.9	53.5 ± 14.3	57.0 ± 26.0
UNa/UK	0.08 ± 0.03	0.15 ± 0.13	0.12 ± 0.10	0.07 ± 0.04	0.10 ± 0.09	0.10 ± 0.10
TTKG	21 ± 7	17 ± 4*	16 ± 2*	17 ± 3	16 ± 3	16 ± 2**
CCl (μL · g−1 · min−1)	2.0 ± 1.0	1.2 ± 0.9	0.9 ± 0.5*	2.2 ± 1.0	2.5 ± 1.7	2.6 ± 1.5
FRCl %	99.51 ± 0.24	99.46 ± 0.33	99.31 ± 0.92*	99.29 ± 0.39	99.62 ± 1.82	99.15 ± 0.49**
COsm (μL · g−1 · min−1)	8.9 ± 1.3	4.6 ± 3.3*	4.2 ± 1.4*	10.1 ± 3.1	8.5 ± 3.3**	8.2 ± 1.9**
UOsm/POsm	1.9 ± 0.5	2.2 ± 0.8	2.2 ± 0.6	2.8 ± 1.2	2.7 ± 1.1	3.1 ± 1.2
CH2O (μL · g−1 · min−1)	−5.1 ± 1.4	−3.1 ± 2.9	−2.3 ± 1.2	−6.9 ± 2.8	−5.7 ± 2.8	−5.6 ± 2.4**

Data are mean ± SD. *p < 0.05 compared to C; **p < 0.05 compared to one week old lambs

CX clearance of electrolyte X, FRX fractional reabsorption of electrolyte X, PRX proximal reabsorption of electrolyte X, DRX distal reabsorption of electrolyte X, UNa/UK urine Na⁺ to K⁺ ratio, TTKG transtubular K⁺ gradient, UOsm urinary osmolality, COsm clearance of osmoles, CH ₂ O free water clearance