Table 3.

Tubular effects of the AT2R antagonist PD 123319 in conscious lambs

Variable	One week			Six weeks
	Control	30 min	60 min	Control	30 min	60 min
CNa (μL · g−1 · min−1)	0.14 ± 0.08	0.23 ± 0.18	0.36 ± 0.44	1.2 ± 0.6**	1.0 ± 0.5**	1.4 ± 1.2**
FRNa %	99.89 ± 0.13	99.85 ± 0.22	99.75 ± 0.30	99.88 ± 0.09	99.86 ± 0.13	99.86 ± 0.14
PRNa %	78.8 ± 11.2	80.1 ± 8.8	77.9 ± 8.3	67.0 ± 20.3**	67.4 ± 20.2**	72.7 ± 21.0**
DRNa %	21.1 ± 11.1	19.8 ± 8.7	21.9 ± 8.1	35.9 ± 19.0**	35.5 ± 18.8**	29.5 ± 20.8**
CK (mL · g−1 · min−1)	0.11 ± 0.10	0.12 ± 0.06	0.09 ± 0.03	0.62 ± 0.28**	0.47 ± 0.12**	0.42 ± 0.18**
FRK %	66.7 ± 16.2	66.7 ± 15.9	62.1 ± 16.2	52.8 ± 27.6	47.3 ± 24.3	68.1 ± 16.7
UNa/UK	0.07 ± 0.05	0.09 ± 0.06	0.14 ± 0.14	0.09 ± 0.05	0.11 ± 0.09	0.10 ± 0.09
TTKG	15 ± 5	15 ± 5	13 ± 5	17 ± 3	14 ± 2*	13 ± 4*
CCl (μL · g−1 · min−1)	2.1 ± 2.1	2.5 ± 2.0	2.1 ± 2.0	2.7 ± 1.8	2.4 ± 1.6	2.8 ± 1.5
FRCl %	99.42 ± 0.39	99.45 ± 0.42	99.30 ± 0.66	99.97 ± 0.02	99.97 ± 0.02	99.97 ± 0.02
COsm (μL · g−1 · min−1)	7.2 ± 3.9	8.1 ± 4.2	7.4 ± 2.8	10.9 ± 3.7	11.4 ± 3.2	11.1 ± 5.4
UOsm/POsm	1.7 ± 0.5	1.7 ± 0.5	2.0 ± 0.7	2.4 ± 0.7	2.8 ± 0.9	2.1 ± 0.7
CH2O (mL · g−1 · min−1)	−3.2 ± 2.7	−3.2 ± 2.4	−2.6 ± 2.1	−7.5 ± 3.3**	−7.1 ± 1.9**	−5.7 ± 3.7

Data are mean ± SD. *p < 0.05 compared to C; **p < 0.05 six weeks compared to one week

V urinary flow rate, CX clearance of electrolyte X, FRX fractional reabsorption of electrolyte X, PRX proximal reabsorption of electrolyte X, DRX distal reabsorption of electrolyte X, UNa/UK urine Na⁺ to K⁺ ratio, TTKG transtubular K⁺ gradient, UOsm urinary osmolality, COsm clearance of osmoles, CH ₂ O free water clearance