Effects of HF/LC diet on expiratory gases and whole body substrate utilization in T1R2-KO mice. Traces (left) and dark cycle average (right) of oxygen consumption (V̇o2; ml·kg−1·h−1; A), carbon dioxide production (V̇co2; ml·kg−1·h−1; B), respiratory exchange ratio (RER; V̇o2/V̇co2; C), carbohydrate oxidation (g·kg−1·h−1; D), and lipid oxidation (g·kg−1·h−1; E) measured for 2 days in CLAMS in WT and T1R2-KO mice in response to 12 wk of LF/HC and HF/LC diets (n = 24/group). Two-way ANOVA with Sidak's multiple comparisons, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.