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. 2016 Feb 16;310(8):E688–E698. doi: 10.1152/ajpendo.00484.2015

Fig. 3.

Fig. 3.

Effects of HF/LC diet on glucose homeostasis in T1R2-KO mice. A: fed (ad libitum) plasma glucose (left), insulin (middle), and insulin sensitivity index (right) assessed by calculating the ratio of plasma insulin to glucose levels for each mouse in WT and T1R2-KO mice during 12-wk control (LF/HC) or HF/LC diet feeding. B: long-term fasting (16 h) plasma glucose (left), insulin (middle), and insulin sensitivity index (right) assessed by calculating the ratio of plasma insulin to glucose levels for each mouse. C: blood glucose levels during ipGTT (1.0 g/kg) as described in methods. D: plasma insulin responses (t = 0 and 30 min post) during ipGTT. E: assessment of insulinogenic index (increment in plasma insulin/increment in plasma glucose) during first 30 min of the ipGTT. F: relative blood glucose responses during ipITT (left) expressed as %change from baseline (set at 100%). G: assessment of rate of glucose disappearance (from baseline to 15 min). In all experiments, n = 12–14/group unless otherwise stated. Two-way ANOVA with Sidak's multiple comparisons, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.