Fig. 11.

A–C: glucagon oscillations may not be observed if the turnover of hormones is too rapid. For this simulation, the parameters for the flux out of the compartment were increased for all 3 hormones. (f_b = 5,000, f_a = 300, f_d = 0.006, ${\overline{\text{g}}}_{{\text{K}}_{\text{ATPb}}}$ = 7,000 pS, and g_KATPd = 0.26 nS). D–F: glucagon does not oscillate if β-cells exhibit fast bursting oscillations. Note the time scale is now in seconds. [g_K(Ca) = 500 pS, J_GK = 0.8, ${\overline{\text{g}}}_{{\text{K}}_{\text{ATPb}}}$ = 8,500 pS, and g_KATPd = 0.26 nS]. Relation of K_ATP conductance to the bell-shaped curve is the same as in Fig. 10.