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Voltage, calcium, and somatostatin secretion for 1 (A–C), 7 (D–F), and 11 mM glucose (G–I). The δ-cell is silent in 1 mM glucose (A). Calcium is low (B), but there is a basal level of secretion (C). Raising glucose (7 mM) depolarizes the cell (D), raises calcium (E), and increases somatostatin secretion (F). Finally, raising glucose even further (11 mM) increases the frequency of the spikes (G). Calcium influx and somatostatin secretion increase further (H and I).
