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. 2015 Aug 27;12(2):273–286. doi: 10.1080/15548627.2015.1082023

Figure 8.

Figure 8.

AUTEN-67 restores nesting behavior and decreases APP levels in a mouse model of Alzheimer disease. (A) Relative changes in the ability of nesting behavior, as compared to controls. Animals were classified into 5 distinct nesting groups (see Materials and Methods and the Fig. S7) at 0 (white columns), 6 (gray columns) and 15 (black columns) weeks of treatments. Administration of AUTEN-67 restores nesting ability of mice transgenic for human amyloid precursor protein (APP). For difference between control and treated animals: P < 0.001, unpaired t test. (B, C) AUTEN-67 decreases Amyloid β levels in the hemibrain of mice transgenic for human APP. (B) AUTEN-67 treatment decreases soluble human amyloid β40 protein levels in the hemibrain of mice transgenic for human APP (**: P < 0.01, paired Student t test). (C) AUTEN-67 treatment decreases insoluble human amyloid β42 protein levels in the hemibrain of mice transgenic for human APP (*: P < 0.05, paired Student t test). Bars represent s.e.