Figure 7.

Schematic diagram of autophagy regulation of nucleotide excision repair in skin carcinogenesis. Autophagy positively regulates nucleotide excision repair through decreasing TWIST1 stability, by which autophagy (1) maintains the proper transcription of XPC through inhibiting the transcription repressor complex E2F4-RBL2 and (2) positively regulates the recruitment of DDB2 to UV-induced DNA damage sites through EP300. Thus autophagy may reduce UV-induced accumulation of mutations, thereby reducing skin tumorigenesis.