Figure 4.

Schematic diagram of proposed tripartite mechanism of anti-hypertensive effect of guava leaves extract. Purine CP: Purine catabolic pathway, XO: Xanthine oxidase, RAP: Rennin-angiotensin pathway, ACE: Angiotensin I-converting enzyme, GLE: Guava leaves extract, O₂ ^•−: superoxide anion radical, ONOO⁻: Peroxynitrite, ↑: Increase. The numbers: 1, 2 and 3 in rectangular boxes indicate the XO inhibition, ACE inhibition; and scavenging of reactive oxygen specie (respectively) by guava leaves extract