Fig. 2.

CF mice have more severe lung function decline in response to chronic LPS exposure. A: representative Alcian/periodic acid-Schiff staining of paraffin-embedded lung tissues from WT and CF mice at T0, T1, and T2 (left) and percentage of goblet cells in CF and WT lungs at T2 (right). B: representative hematoxylin-eosin staining of lung parenchyma of WT and CF mice at T0 and T3 (left), at which time alveoli of CF mice showed the highest degree of enlargement and disruption, and changes in chord length from T0 to T3 in WT and CF mice. Scale bars = 20 μm. C: pulmonary function tests. Top: airway resistance. Bottom: total lung capacity (TLC). Values are means ± SD. *P < 0.05.