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Activation of OSTα and OSTβ by NF-κB. Huh-7 cells were transiently transfected with NF-κB p65, p50, and plasmid vectors containing OSTα or OSTβ promoter sequences that included the NF-κBE linked to luciferase as reporter. Transactivation of the OSTα (A) and OSTβ (B) promoter constructs by NF-κB subunits was monitored by luciferase activity. NF-κB p65 and p50 expression (A and B) individually or together dos dependently activated the OSTα and OSTβ promoters in Huh-7 cells. *P < 0.05.
