Table 3.

Summary of subgroup analysis by localization of survivin expression

Contrasts	Subcellular locolization	Study (n)	Combined RR (95 % CI)	P(Z)	I2	P(Q)
NSCLC vs. Control	All	19	7.16(4.63-11.07)	<0.001	58.1 %	0.001
	Cytoplasma	9	7.14(4.19-12.16)	<0.001	43.8 %	0.076
	Cytoplasma or nuclearus	5	3.96(1.93-8.14)	<0.001	46.1 %	0.115
	Cytoplasma and nuclearus	2	17.41(1.2-252.4)	0.036	70.5 %	0.065
Squamous cell carcinoma vs. Adenocarcinoma	All	22	0.99(0.92, 1.07)	0.866	7.0 %	0.367
	Cytoplasma	11	0.98(0.88-1.08)	0.641	0 %	0.767
	Cytoplasma or nuclearus	6	0.98(0.83-1.15)	0.771	30.8 %	0.204
	Cytoplasma and nuclearus	2	1.74(1.12-2.71)	0.013	0 %	0.324
Well/Moderately differentiated vs. Poor differentiated	All	21	0.80(0.73-0.87)	<0.001	45.4 %	0.013
	Cytoplasma	8	0.84(0.75-0.93)	0.001	19.6 %	0.274
	Cytoplasma or nuclearus	7	0.68(0.52-0.88)	0.003	68.9 %	0.004
	Cytoplasma and nuclearus	2	0.73(0.46-1.16)	0.179	42.7 %	0.186
TNMI/II stage vs. TNM III/IVstage	All	26	0.75(0.67-0.84)	<0.001	72.7 %	<0.001
	Cytoplasma	12	0.83(0.69-1.01)	0.059	74.1 %	<0.001
	Cytoplasma or nuclearus	8	0.73(0.61-0.88)	0.001	74.5 %	<0.001
	Cytoplasma and nuclearus	2	0.73(0.41-1.29)	0.278	59.7 %	0.115
Lymph node metastasis vs. Non lymph node metastasis	All	25	1.14(1.01-1.29)	0.035	71.5 %	<0.001
	Cytoplasma	10	1.24(1.07-1.44)	0.005	53.1 %	0.024
	Cytoplasma or nuclearus	9	1.12(0.89-1.41)	0.352	76.6 %	<0.001
	Cytoplasma and nuclearus	2	0.96(0.32-2.91)	0.949	83.1 %	0.015
Small Tumor vs. Big Tumor	All	11	0.95(0.86-1.05)	0.336	18.1 %	0.272
	Cytoplasma	6	0.97(0.79-1.19)	0.738	48.3 %	0.085
	Cytoplasma or nuclearus	4	0.92(0.83-1.04)	0.226	0 %	0.565
	Cytoplasma and nuclearus	1	1.09(0.71-1.67)	0.691	/	/