Table 2.

Performance Measures of Digital Screening Mammography with and without CAD

Performance Measure	CAD		No CAD		CAD		No CAD		Adjusted OR*		P value
	Events	Exams	Events	Exams	Mean	95% CI	Mean	95% CI	OR	95% CI
Cancers detected per 1000 exams
Total	2145	495,818	558	129,807	4.06	(3.8, 4.4)	4.10	(3.6, 4.6)	0.99	(0.84, 1.15)	0.86
Invasive	1485	495,818	408	129,807	2.91	(2.7, 3.1)	3.05	(2.7, 3.5)	0.92	(0.77, 1.08)	0.30
DCIS	660	495,818	150	129,807	1.19	(1.0, 1.3)	0.95	(0.7, 1.2)	1.39	(1.03, 1.87)	0.031
Interval cancers per 1000 exams
Total	375	495,818	81	129,807	0.76	(0.68, 0.84)	0.62	(0.50, 0.78)	1.14	(0.87, 1.50)	0.33
Invasive	327	495,818	72	129,807	0.65	(0.57, 0.74)	0.55	(0.42, 0.71)	1.09	(0.82, 1.46)	0.54
DCIS	48	495,818	9	129,807	0.10	(0.07, 0.13)	0.03	(0.00, 0.24)	1.59	(0.72, 3.51)	0.25
Sensitivity
Total	2145	2520	558	639	85.3%	(83.6, 86.9)	87.3%	(84.5, 89.7)	0.81	(0.60, 1.10)	0.18
Invasive	1485	1812	408	480	82.1%	(80.0, 84.0)	85.0%	(81.5, 87.9)	0.83	(0.59, 1.17)	0.28
DCIS	660	708	150	159	93.2%	(91.1, 94.9)	94.3%	(89.4, 97.1)	0.88	(0.37, 2.07)	0.76
Specificity
Total	444,356	493,298	118,025	129,168	91.6%	(91.0, 92.2)	91.4%	(90.6, 92.0)	1.02	(0.94, 1.11)	0.58
Invasive	444,404	494,006	118,034	129,327	91.5%	(90.9, 92.1)	91.3%	(90.5, 91.9)	1.02	(0.94, 1.11)	0.58
DCIS	444,683	495,110	118,097	129,648	91.4%	(90.7, 92.0)	91.0%	(90.3, 91.7)	1.04	(0.96, 1.13)	0.36
Recall rate per 100 exams	51,087	495,818	11,701	129,807	8.7	(8.1, 9.4)	9.1	(8.4, 9.8)	0.96	(0.89, 1.04)	0.35

CAD, computer-aided detection; OR, odds ratio; CI, confidence interval; DCIS, ductal carcinoma in situ

^*Odds ratio for CAD vs . No CAD adjusted for site, age group, race/ethnicity, time since prior mammogram and calendar year of the exam using mixed effects model with random effect for exam reader and varying with CAD use.