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. Author manuscript; available in PMC: 2016 Apr 19.
Published in final edited form as: Nature. 2014 Nov 27;515(7528):563–567. doi: 10.1038/nature14011

Extended Data Figure 4. Antitumour activity of MPDL3280A by PD-L1 immunohistochemistry (IHC) status.

Extended Data Figure 4

a, The overall objective response rate (ORR; best response of complete response (CR) and partial response (PR)), stable disease (SD) as the best response rate and progressive disease (PD) as the best response rate for patients with non-small cell lung cancer (NSCLC) who received MPDL3280A by PD-L1 IHC (tumour-infiltrating immune cell (IC)) status. Overall, 53 patients with NSCLC were evaluated: 6 patients had an IHC (IC) score of 3; 7 patients had a score of 2; 13 patients had a score of 1; and 20 patients had a score of 0. Seven patients had an unknown IHC status (data not shown). Patients with no post-first dose assessment were not estimable and not plotted (1 in IHC 1 and 1 in IHC 2), but were included in the denominator for purposes of calculating ORR. Using a logistic regression model, PD-L1 by IHC (IC) was significantly associated with response to MPDL3280A (P = 0.015). b, The ORR, SD as best response rate, and PD as best response rate for patients with all tumour types who received MPDL3280A by PD-L1 IHC (IC) status. Patients with no post-first dose assessment were not estimable (NE) and not plotted (1 in IHC 0, 2 in IHC 1, 1 in IHC 2 and 1 in IHC 3), but were included in the denominator for purposes of calculating ORR. Using a logistic regression model, PD-L1 by IHC (IC) was significantly associated with response to MPDL3280A (P = 0.007). c, The ORR, SD as best response rate, and PD as best response rate for patients with NSCLC who received MPDL3280A by PD-L1 IHC (TC) status. Overall, 53 patients with NSCLC were evaluated: 8 patients had an IHC score of 3; 1 patient had a score of 2; 3 patients had a score of 1; and 34 patients had a score of 0. Seven patients had an unknown IHC status (data not shown). Patients with no post-first dose assessment were not estimable and not plotted (2 in IHC 0), but were included in the denominator for purposes of calculating ORR. All responses were confirmed except for in 1 patient. Using a logistic regression model, PD-L1 by IHC (TC) did not meet statistical significance for association with response (P = 0.920). d, The ORR and SD and PD best response rates for patients with all tumour types who received MPDL3280A by PD-L1 IHC (TC) status. Overall, 175 patients with all tumour types were evaluated: 15 patients had an IHC score of 3; 3 patients had a score of 2; 11 patients had a score of 1; and 121 patients had a score of 0; 25 patients had an unknown IHC status (data not shown). Patients with no post-first dose assessment were not estimable and not plotted (3 in IHC 0, 1 in IHC 1 and 1 in IHC 3), but were included in the denominator for purposes of calculating ORR. All responses were confirmed except for in 1 patient with NSCLC, 1 patient with RCC and 2 patients with melanoma. Using a logistic regression model, PD-L1 by IHC (TC) did not meet statistical significance for the association with response (P = 0.079).