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. 2016 Apr 18;14:32. doi: 10.1186/s12915-016-0253-6

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© Calero-Cuenca et al. 2016

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — aPKC recycling in the epithelial cells. Schematic model of aPKC transport to the membrane in Rab11-Nuf RE vesicles (left): (1) Vesicles derived from the RE (REdv) containing aPKC move to the apico-lateral site via Rab11-Nuf. (2) aPKC interacts with the apical complexes and becomes active. (3) Active aPKC is able to interact with and phosphorylate Nuf. This phosphorylation release aPKC-Nuf interaction (red dash-line box on the right) (4) inhibiting its apico-lateral localization. aPKC atypical PKC, RE recycling endosome, Nuf nuclear fallout