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. 2016 Mar 21;18:e4. doi: 10.1017/erm.2016.3

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© Cambridge University Press 2016

This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike licence (http://creativecommons.org/licenses/by-nc-sa/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the same Creative Commons licence is included and the original work is properly cited. The written permission of Cambridge University Press must be obtained for commercial re-use.

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Figure 2. — Effect of a miR-124 mimics and inhibitor on rat seizure behavioural activities. (a) Fluorescent image showing positive expression of the miR-124 mimics and miR-124 inhibitor in the DG of the hippocampus. The blue arrow indicates a granule cell; Scale bar, 100 µm. (b) miR-124 levels in the hippocampus 72 h after intrahippocampal injection of the miR-124 mimics (0.2/0.6/1.0 nm) and mimics control (1.0 nm). *P < 0.05, compared with the control, n = 3 in each group. (c) Effect of intrahippocampal injection of the miR-124 mimics (0.2/0.6/1.0 nm) and mimics control (1.0 nm) on the percentage of rats with generalised tonic–clonic seizures (GTCS) in pilocarpine-induced seizure rat models. *P < 0.05, compared with the control, n = 8 in each group. (d) Effect of intrahippocampal miR-124 mimics (0.2/0.6/1.0 nm) and mimics control (1.0 nm) injection on the latency of seizures in pilocarpine-induced rat models. *P < 0.05, compared with the control, n = 8 in each group. (e) Effect of intrahippocampal miR-124 mimics (1.0 nm) and mimics control (1.0 nm). injection on the percentage of rats with generalised tonic–clonic seizures (GTCS) in PTZ-induced seizure rat models. *P < 0.05, compared with the control, n = 8 in each group. (f) Effect of intrahippocampal miR-124 mimics (1.0 nm) and mimics control (1.0 nm) injection on the latency of seizures in PTZ-induced seizure rat models. *P < 0.05, compared with the control, n = 8 in each group. (g) miR-124 levels in the hippocampus 72 h after intrahippocampal injection of the miR-124 inhibitor (4.0 nm) and inhibitor control (4.0 nm). *P < 0.05, compared with the control, n = 5 in each group. (h) No statistically considerable differences was found between the percentage of rats with GTCS in control, inhibitor control and inhibitor groups. n = 8 in each group. (i) Effect of intrahippocampal miR-124 inhibitor (4.0 nm) and inhibitor control (4.0 nm) injection on the latency of seizures in pilocarpine-induced rat models. *P < 0.05, compared with the control, n = 8 in each group.

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