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. 2016 Mar 21;18:e4. doi: 10.1017/erm.2016.3

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© Cambridge University Press 2016

This is an Open Access article, distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike licence (http://creativecommons.org/licenses/by-nc-sa/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the same Creative Commons licence is included and the original work is properly cited. The written permission of Cambridge University Press must be obtained for commercial re-use.

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Figure 4. — Effect of miR-124 on excitatory neurotransmission after seizure activity. (a) Representative traces of mEPSC recorded in hippocampal pyramidal cells in control (without seizure inducing) group, mimics group and mimics control group. (b, c) Cumulative fractions of amplitude and interevent interval (n = 5 in individual groups). (d) Representative traces showing dual components (mediated by AMPARs and NMDARs, as indicated) were recorded from CA1 neurons by holding the membrane potential at +40 mV. (e, f) Sample traces showing AMPAR- (e) and NMDAR- (f) mediated components in control (without seizure inducing) and mimics and mimics control injection in pilocarpine-induced seizure rats, respectively. (g) Summary of AMPAR-mediated currents. (h) Summary of NMDAR-mediated currents. *P < 0.05, compared with the control (n = 5). ▲P < 0.05, compared with the mimics control, n = 5.

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