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. 2016 Mar 21;18:e4. doi: 10.1017/erm.2016.3

Figure 5.

Figure 5.

Effect of miR-124 on the expression of NMDAR1 and GLUR1 in the hippocampus. (a) Diagram of the CREB1-3′-UTR with potential binding-sites for miR-124. (b) Relative luciferase activity of reporters, including WT or mutant CREB1 and NMDAR1 3′-UTR co-transfected with NC or miR-124 mimics. *indicates significant difference at P  <  0.01, respectively. (c) Sample Western blots showing surface and total levels of GLUR1 subunits in normal (without seizure inducing) and pilocarpine-induced seizure rats without treatment (control), and in rats treated with mimics control and mimics. (d) Sample Western blots showing the surface and total levels of expression of NMDAR1 subunits in normal (without seizure inducing) and pilocarpine-induced seizure rats without treatment (control), and in rats treated with mimics control and mimics. (e) Summary showing the surface expression and the total and surface/total ratios of GLUR1 subunits. *P < 0.05, compared with the control. ▲P < 0.05, compared with the mimics control, n = 3. (f) Summary showing the surface expression and the total and surface/total ratios of NMDAR1 subunits. ▲P < 0.05, compared with the mimics control, n = 3.

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