TABLE 3.
Top six potential TTP targets with highly conserved TTP binding sites in the 3′UTRa
| Gene symbol | Product | Fold change |
Significant |
TTP binding site | ||
|---|---|---|---|---|---|---|
| DKO | TKO | DKO | TTP KO | |||
| Tmcc2 | Transmembrane and coiled coil domain family 2 | 1.5 | 23.2 | No | Yes | One 8-mer–9-mer overlap (mouse, rat), one 9-mer highly conserved |
| Tfrc | Transferrin receptor (p90, CD71) | 1.1 | 18.5 | No | Yes | Two 8-mers highly conserved |
| Abcg4 | ATP binding cassette, subfamily G, member 4 | 1.0 | 17.0 | No | Yes | One 7-mer highly conserved |
| E2f8 | E2F transcription factor 8 | 1.4 | 13.0 | No | Yes | One 8-mer highly conserved |
| Sox6 | SRY (sex-determining region Y)-box 6 | 1.0 | 11.9 | No | Yes | Five 8-mers, one 7-mer, all highly conserved |
| Cdc6 | Cell division cycle 6 | 1.4 | 11.7 | No | Yes | One 8-mer highly conserved |
a
The top 6 potential TTP target mRNAs were upregulated in the triple KO spleens but not in the double KO spleens and contain highly conserved potential TTP binding sites in their 3′UTR. DKO, double knockout; TKO, triple knockout.