TABLE 5.
Replication of H7N9 influenza viruses in ferrets
| Characteristic | Value(s) for: |
||||
|---|---|---|---|---|---|
| Shv/Egypt/07 | Anhui/1/13f | Taiwan/1/13 | HK/5942/13 | BC/1/15 | |
| Clinicala | |||||
| Feverb | 1.6 | 1.6 | 1.9 | 1.8 | 1.8 |
| wt lossc | 2.2 | 8.8 | 4.4 | 15.1 | 11.3 |
| Virus sample source and titerd | |||||
| CWe | 0/3 | 6/11 | 1/3 | 3/3 | 6/6 |
| RSe | 0/3 | 7/11 | 1/3 | 0/3 | 1/6 |
| Conj | 0/3 | 1.8 (1/3) | 2.2 ± 0.4 (2/3) | 0/3 | 1.8 ± 0.4 |
| Int | 0/3 | 0/3 | 1.7 ± 0.5 (2/3) | 1.6 (1/3) | 2.4 (1/3) |
| Nas Tur | 5.8 ± 0.4 | 6.2 ± 0.2 | 5.6 ± 0.6 | 5.4 ± 0.4 | 6.1 ± 0.6 |
| Trachea | 3.5 ± 0.6 (2/3) | 5.5 ± 0.6 | 5.3 ± 0.8 | 3.3 (1/3) | 5.1 ± 0.4 |
| Lung | 3.5 ± 2.2 (2/3) | 5.6 ± 0.3 | 5.0 ± 0.9 | 5.0 ± 1.1 | 6.5 ± 0.1 |
| OB | 0/3 | 4.9 (1/3) | 0/3 | 4.0 (1/3) | 4.1 ± 2.1 (2/3) |
| Bn Ant | 0/3 | 2.7 (1/3) | 0/3 | 1.8 ± 0.7 | 3.8 ± 0.1 (2/3) |
Clinical signs, symptoms, and observations detected through 14 days p.i.
Mean maximum rise in body temperature in degrees centigrade (baseline body temperature, 37.7 to 39.3°C).
Percent mean maximum weight loss in ferrets.
Unless specified otherwise, virus titers are expressed as the mean log10 PFU/g or ml ± SD among ferrets with positive virus detection on day 3 p.i. (data are representative of 3 ferrets examined, unless denoted in parentheses). The limit of virus detection was 10 PFU. Conj, surrounding conjunctival tissue; Int, pooled (duodenum, jejunum, and ileum) intestinal tissue; Nas Tur, nasal turbinates; OB, olfactory bulb; Bn Ant, anterior brain.
Number of ferrets with detectable virus in conjunctival washes (CW) or rectal swabs (RS) collected on days 1, 3, and 5 p.i./total number of ferrets tested.
Includes data published previously in reference 28.