FIG 3.

Nonparametric correlation between E1E2 ELISA binding and neutralization. (A, B) The number of HCVpp neutralized was plotted against the ELISA binding rank for panel XG (A) and panel Gt1 (B). (C) The neutralization activity of antibodies from the full cohort against HCVpp in panel XG and the HCVcc viruses (1A-HQL, JFH-1, 2B1.1/JFH1) was analyzed, and the neutralization rank in the HCVcc and HCVpp systems was plotted. (D) For those gt1-infected individuals whose antibodies were tested for reactivity against HCVpp in both panels, the number of HCVpp isolates in panel XG neutralized was plotted against the number of HCVpp isolates in panel Gt1 neutralized. Spearman's rho correlation coefficient was calculated for all graphs.