FIG 4.

Association of liver fibrosis with neutralization. The neutralization of HCVpp in panel XG by IgGs from the full CHCV patient cohort (A, C) or HCVpp in panel Gt1 by IgGs from the gt1-infected subgroup (B, D) was determined as described in the legend to Fig. 2. (A, B) The broadly and narrowly neutralizing groups were defined as described in the legend to Fig. 2, and transient elastography values, measured using a FibroScan instrument, were compared using the Mann-Whitney U test. (C, D) The number of HCVpp isolates neutralized by IgG from individuals with and without cirrhosis was compared using the Mann-Whitney U test.