TABLE 3.

Amino acidic changes at the consensus level among the DENV-3 isolates collected at different time points during the Cuban epidemic, 2001 to 2002

Sample no.	Sample code	Amino acid residue of the viral protein at the indicated position:a
		C	E		NS1	NS2A		NS2B				NS3		NS4A	NS4B	NS5
		39	198	329	256	4	195	33	59	60	93	60	155	39	18	190	246	250	371	637	830
1	Cuba_15_01	K	T	V	H	K	A	V	I	T	S	H	V	R	E	I	H	T	R	H	V
2	Cuba_26_01										N
3	Cuba_73_01										N				D
4	Cuba_118_01	N			Y	E	T		V		N	Y	I	K		V				R	I
5	Cuba_167_01	N			Y	E	T		V		N	Y	I	K		V				R	I
6	Cuba_463_01										N							A
7	Cuba_492_01										N							A
8	Cuba_504_01										N
9	Cuba_513_01										N
10	Cuba_523_01							L			N						Y
11	Cuba_546_01										N
12	Cuba_547_01			A							N
13	Cuba_553_01										N
14	Cuba_557_01			A							N
15	Cuba_558_01										N
16	Cuba_568_01										N								K
17	Cuba_580_01										N
18	Cuba_16_02									I	N
19	Cuba_11_02										N
20	Cuba_17_02		A								N
21	Cuba_20_02										N
22	Cuba_21_02										N

^aThe reference sequence of Cuba_15_2001 is shown in boldface. Only substitutions are shown. Samples 4 and 5 correspond to a different lineage.