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Schematic representation of the effect of Nrf2 deficiency on skeletal muscle regeneration after injury. Under normal physiologic conditions, when redox homeostasis is being maintained by the transcription factor Nrf2; activation, proliferation, and differentiation of satellite cells occurs to regenerate skeletal muscle after injury. However, when the redox imbalance occurs due to loss and/or inactivation of Nrf2, skeletal muscle regeneration could be delayed.
