Figure 6.

Loss of Nrf2 affects the expression of skeletal muscle regeneration markers during CTX-mediated TA muscle injury and regeneration. A, C) Immunoblot analyses for PAX7 and MYOD1 (A) and myogenin (C) in TA muscle of PBS and CTX-treated WT and Nrf2^−/− mice. B, D) Relative intensity of the PAX7 and MYOD1 (B) and myogenin (D) protein signals normalized to GAPDH was calculated using ImageJ software; n = 4/d per group. Statistical significance was calculated by 1-way ANOVA. ^#P < 0.05 PBS vs. CTX-WT, *P < 0.05 CTX-WT vs. Nrf2^−/−.