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. Author manuscript; available in PMC: 2017 Mar 24.
Published in final edited form as: J Med Chem. 2016 Mar 15;59(6):2579–2595. doi: 10.1021/acs.jmedchem.5b01780

Scheme 1a.

Scheme 1a

aReagents and conditions: (i) Methyl-4-hydroxybenzoate, K2CO3/MEK, μW, 100°C, 2×20 min; (ii) NaOH, THF. EtOH, H2O, 80°C, 12 h; (iii) NaBH4, THF, r.t., 1 h; (iv) H2NOH.HCl/MeOH, pyridine, reflux, 6 h; (v) K2CO3 (2M)/MeOH, reflux, 80°C.