Scheme 2a.
aReagents and conditions: (i) AlCl3, CH2Cl2, r.t., overnight; (ii) K2CO3 (2M)/MeOH, reflux, 80°C,; (iii) (CH2OH)2, pTsOH, toluene, reflux, overnight; (iv) (CH2SH)2, BF3.Et2O, CH2Cl2, r.t., 0.5–1h.
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