Table 1.
IC50 values and 95% confidence intervals of the IC50 for the RAMBAs and synthetic retinoids against CYP26A1 and CYP26B1 for compounds 1, 3, 40, and the naphthyl analogues 11b, 13b and 15b.
| |||
|---|---|---|---|
| Compound | R1 | Activity (μM) | |
| CYP26A1 | CYP26B1 | ||
| 1 | _ | 1.9 (1.5–2.3) | 0.018 (0.013–0.027) |
| 3 | _ | 0.0051a (0.0034–0.0068) | 0.00046a (0.000069–0.00085) |
 40 |
_ | 13.5 (8.6–21.3) | 5.9 (2.6–13.3) |
| 11b |
|
1.63 (0.95–2.9) | 0.52 (0.4–0.7) |
| 13b |
|
0.11 (0.05–0.24) | 1.03 (0.62–1.7) |
| 15b |
|
0.06 (0.04–0.10) | 1.03 (0.69–1.5) |
a
Inhibition constant determined based on tight binding quadratic equation.