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. Author manuscript; available in PMC: 2017 Mar 24.
Published in final edited form as: J Med Chem. 2016 Mar 15;59(6):2579–2595. doi: 10.1021/acs.jmedchem.5b01780

Table 1.

IC50 values and 95% confidence intervals of the IC50 for the RAMBAs and synthetic retinoids against CYP26A1 and CYP26B1 for compounds 1, 3, 40, and the naphthyl analogues 11b, 13b and 15b.

graphic file with name nihms774586u2.jpg
Compound R1 Activity (μM)
CYP26A1 CYP26B1
1 _ 1.9 (1.5–2.3) 0.018 (0.013–0.027)
3 _ 0.0051a (0.0034–0.0068) 0.00046a (0.000069–0.00085)
graphic file with name nihms774586t1.jpg
40
_ 13.5 (8.6–21.3) 5.9 (2.6–13.3)
11b graphic file with name nihms774586t2.jpg 1.63 (0.95–2.9) 0.52 (0.4–0.7)
13b graphic file with name nihms774586t3.jpg 0.11 (0.05–0.24) 1.03 (0.62–1.7)
15b graphic file with name nihms774586t4.jpg 0.06 (0.04–0.10) 1.03 (0.69–1.5)
a

Inhibition constant determined based on tight binding quadratic equation.