Table 1. Inhibitory Potencies of Compounds 4a–4f Determined Using an in Vitro IN Assay^a.

		IC50 (μM)
no.	R	3′-processing	strand transfer
4ab	H	2.5 ± 0.3	0.019 ± 0.002
4b	(CH2)3OH	4.3 ± 0.6	0.0113 ± 0.0027
4c	(CH2)5OH	8.2 ± 1.2	0.0027 ± 0.0004
4d	(CH2)6OH	19 ± 1	0.00059 ± 0.00011
4e	(CH2)8OH	32 ± 6	0.0054 ± 0.0008
4f	(CH2)2 SO2Ph		0.0037 ± 0.0013

^aAssays were performed using a gel-based protocol with Mg²⁺ cofactor as described.⁴³

^bPreviously reported values.²⁴