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. Author manuscript; available in PMC: 2016 Apr 19.
Published in final edited form as: Nature. 2016 Mar 16;531(7595):471–475. doi: 10.1038/nature17157

Extended Data Figure 7. In the Eμ-Myc model, Trp53 and Eif5a cooperate in tumorigenesis.

Extended Data Figure 7

Two-colour assay for the cooperation of Trp53 and Eif5a deficiencies on lymphoma genesis. Eμ-Myc HSPCs retrovirally co-transduced with GFP- (shEif5a or shRen) and mCherry- linked shRNAs (shRen, shp53) were transplanted into sublethally-irradiated syngeneic recipients (n = 5 per group). a, b, The resulting tumours were analysed by flow cytometry (a) and the percentage of GFP+ mCherry+ lymphoma cells in each configuration was quantified (b). Error bars represent s.d. *P < 0.05, ***P < 0.001 (two tailed t-test).