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. 2015 May 16;138(7):2005–2019. doi: 10.1093/brain/awv128

Figure 1.

Figure 1

Endophilin-B1b/c is decreased in hippocampus and cortex of symptomatic APP/PSEN1 mice. (A) Hippocampus and cortex of 10-month-old APP/PSEN1 mice and wild-type littermates were analysed for endophilin-B1 (Endo-B1) by western blot. Actin was used as a loading control. (B and C) Densitometric quantification of western blots reveals that endophilin-B1b/c (B), but not endophilin-B1a (C) is decreased in hippocampus and cortex of 10-month-old APP/PSEN1 mice. *P < 0.05 versus control, Student’s t-test (n = 7 mice per group). Endophilin-B1b/c (D) and endophilin-B1a (E) in 6-week-old presymptomatic APP/PSEN1 mice are not different from wild-type controls (n = 6).