TABLE 1.
Household demographics of subjects receiving FMT for recurrent CDI and index control subjects
| Demographic | Value for group |
||
|---|---|---|---|
| Peri-FMT (n = 8) | Post-FMT (n = 8) | Controld (n = 8) | |
| Mean age (yr) ± SD | 69 ± 14 | 70 ± 14 | 68 ± 7 |
| No. (%) of females | 5 (62) | 6 (75) | 8 (100) |
| Mean time (days) since FMT ± SD (median) | 2.4 ± 5.6a,c (2) | 443 ± 280b,c (399) | NA |
| Mean duration of recurrent CDI (mo)e ± SD | 10.1 ± 8.3 | 7.6 ± 3.7 | NA |
| Mean no. of CDI episodes ± SD | 3.6 ± 1.0 | 4.3 ± 1.3 | NA |
| No. (%) of CDI patients requiring hospitalization | 3 (38) | 5 (67) | NA |
| No. (%) of patients with healthcare exposure in past 6 mof | 8 (100) | 6 (75) | 6 (75) |
| No. (%) of patients with antibiotic use in past 12 mog | 5 (63) | 5 (63) | 1 (13) |
| No. (%) of patients using acid-reducing medicationh | 1 (13) | 5 (63) | 1 (13) |
| No. (%) of patients with diarrhea at time of study visit | 3 (38) | 2 (25) | 1 (13) |
| Total no. of household members (mean no. of household members per household group, range) | 10 (1.25, 0–5) | 6 (0.75, 0–3) | 7 (0.88, 0–3) |
| Mean age (yr) of household members ± SD | 59 ± 15 | 58 ± 21 | 57 ± 24 |
| No. of pets (mean no. of pets per household) | 8 (0.8) | 6 (0.75) | 2 (0.25) |
| Mean household cleaning frequency scorei ± SDc | 4 ± 0.6c | 3.2 ± 0.5c | 3.4 ± 0.7 |
| No. (%) of patients reporting bleach cleaning | 6 (75) | 6 (75) | 4 (50) |
| Mean hand washing scorej ± SD | 4.8 ± 0.7 | 5 ± 0 | 4.9 ± 0.4 |
| Mean CDI knowledge scorek ± SD | 6.8 ± 1.3 | 6.6 ± 2.4 | 7.9 ± 1.9 |
| No. (%) of index subjects with ≥2 underlying medical conditionsl | 5 (62)m | 4 (50) | 0 (0)m |
The mean time since FMT as shown excludes a single outlier case (−217 days) for whom FMT was delayed unexpectedly after the study visit due to chemotherapy. Including this case, the mean time since FMT ± the standard deviation is −25 ± 78 days.
The mean ± standard deviation for the post-FMT group at 6 months is 197 ± 36 days; the mean ± standard deviation for the post-FMT group at 2 years is 689 ± 143 days.
P < 0.05 for comparison of peri-FMT to post-FMT households using Student's t test (two sided).
NA, not applicable; no CDI or FMT in control subjects.
Duration is prior to FMT or study visit (in the case of one subject whose FMT was delayed unexpectedly for 217 days) for the peri-FMT group or prior to FMT for the post-FMT group.
Exposure is defined as >1 h spent in a hospital, emergency room/urgent care center, outpatient clinic, hemodialysis unit, or long-term-care facility.
Antibiotic use did not include antibiotics used for CDI therapy.
Proton pump inhibitors and/or H2 receptor blockers.
Household cleaning frequency is the mean cleaning frequency for each environmental surface sampled in the household, with 5 indicating a frequency of >1 cleaning/week, 4 indicating 1 cleaning/week, 3 indicating cleaning every other week, 2 indicating 1 cleaning/month, 1 indicating <1 cleaning/month, and 0 indicating never.
A score of 5 is always, 4 is most of the time, 3 is some of the time, 2 is rarely, and 1 is never.
Number of questions correct out of 9 total questions regarding CDI risk factors.
Underlying conditions assessed included diabetes, lung disease, heart disease (including hypertension), liver disease, cancer, rheumatologic disease, inflammatory bowel disease, and stem cell or solid-organ transplantation.
P < 0.05 for comparison of peri-FMT to control households (by two-sided Fisher's exact test).