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Abrogation of the male dominance of PH in the chronic hypoxia model in mice with heterozygous SM22-Cre, STAT5a/b+/− deletion (7 weeks' of hypoxia; n= 5 per group). Panel A, RVSP; Panel B, RVH; Panels C, PA remodeling in terms of wall thickness; Panel D: PA remodeling in terms of SMA-positive vessels; Panel E, Van Gieson's elastin staining. Scale bar = 45 µm). *P <0.05. Adapted from Sehgal et al (2014).83
