Table 1.
Anthropometric and biochemical markers.
| WT SD | WT HFHF-STZ | AT2R-KO SD | AT2R-KO HFHF-STZ | |
|---|---|---|---|---|
| Weight gain (%) | 19.4 ± 2.2 | 21.7 ± 2.5 | 5.9 ± 1.5a | 10.9 ± 2.7b |
| Blood glucose (mM) | 4.2 ± 0.2 | 6.1 ± 0.5a | 7.3 ± 0.5a | 8.7 ± 0.7b |
| Blood glucose AUCOGTT (mM.120 min−1) | 2131 ± 98 | 2155 ± 84 | 2029 ± 111 | 2248 ± 69 |
| Plasma NEFA (µM) | 604 ± 87 | 558 ± 74 | 708 ± 40 | 667 ± 70 |
| Plasma triglycerides (µM) | 371 ± 33 | 286 ± 41 | 301 ± 33 | 264 ± 46 |
| Plasma insulin (pg.mL−1) | 1993 ± 726 | 1040 ± 329 | 309 ± 110a | 293 ± 179 |
| Plasma leptin (pg.mL−1) | 1718 ± 394 | 2731 ± 899 | 715 ± 207a | 1821 ± 737 |
| Heart weight (mg) | 158.4 ± 5.6 | 134.2 ± 2.4a | 129.0 ± 5.2a | 135.8 ± 7.0 |
| Liver weight (mg) | 1233 ± 47 | 906 ± 43a | 1152 ± 76 | 961 ± 8c |
| Skeletal muscle (Gastrocnemius) weight (mg) | 117.6 ± 10.2 | 125.5 ± 15.0 | 105.8 ± 8.4 | 125.0 ± 9.9 |
| Visceral adipose tissue weight (mg) | 903.1 ± 125.6 | 771.8 ± 162.0 | 648.2 ± 152.6 | 878.0 ± 193.2 |
Values are means ± SE from 9–10 animals per group. Wild-type (WT) and AT2R-knockout-out (KO) mice were fed for 6 weeks either with standard laboratory rodent diet (SD) or with a high-fat/high-fructose with small injection of streptozotocin (HFHF-STZ). Statistical analysis was performed using Mann-Whitney test. a : P < 0 .05 vs. WT SD ; b : P < 0 .05 vs. WT HFHF-STZ ; c : P < 0 .05 vs. AT2R-KO SD.