Table 3.
Biochemical markers evaluated in serum and urine of Wistar and Sprague-Dawley (SD) rats fed either with standard (St) or high-fat (HF) diet during 17 weeks
|
Wistar Rat |
SD Rat |
Two-way ANOVAP values |
|||||
|---|---|---|---|---|---|---|---|
| St | HF | St | HF | Diet | Strain | Interaction | |
| Serum | |||||||
| Creatinine (mg/dL) | 0.40 ± 0.04 | 0.52 ± 0.02 | 0.67 ± 0.04 | 0.67 ± 0.03 | 0.098 | <0.001 | 0.062 |
| Urea (mg/dL) | 30.2 ± 0.7 | 36.6 ± 2.3 * | 35.0 ± 2.4 | 34.0 ± 0.7 | 0.121 | 0.513 | 0.039 |
| Uric Acid (mg/dL) | 0.83 ± 0.08 | 0.92 ± 0.12 | 1.00 ± 0.27 | 0.85 ± 0.12 | 0.773 | 0.699 | 0.425 |
| Total Cholesterol (mg/dL) | 103.8 ± 7.2 | 105.6 ± 8.6 | 101.8 ± 8.2 | 80.0 ± 4.0 | 0.177 | 0.069 | 0.115 |
| Triglycerides (mg/dL) | 150.2 ± 21.3 | 185.4 ± 14.9 | 62.7 ± 12.5 | 40.7 ± 3.1 | 0.654 | <0.001 | 0.064 |
| Albumin (g/dL) | 3.7 ± 0.1 | 3.5 ± 0.1 | 3.3 ± 0.2 | 2.9 ± 0.1 | 0.048 | 0.003 | 0.296 |
| Alkaline Phosphatase (U/L) | 79.7 ± 5.2 | 132.0 ± 14.9 * | 141.0 ± 14.2 ‡ | 118.0 ± 9.7 | 0.214 | 0.052 | 0.004 |
| AST (U/L) | 191.3 ± 39.0 | 168.6 ± 20.8 | 130.7 ± 28.4 | 135.8 ± 26.1 | 0.774 | 0.138 | 0.649 |
| ALT (U/L) | 47.2 ± 4.6 | 41.4 ± 4.1 | 51.5 ± 3.9 | 59.2 ± 9.3 | 0.883 | 0.095 | 0.296 |
| Urine | |||||||
| Creatinine (g/day) | 0.010 ± 0.000 | 0.012 ± 0.002 | 0.016 ± 0.004 | 0.017 ± 0.002 | 0.606 | 0.023 | 0.825 |
| Urea (g/day) | 0.17 ± 0.02 | 0.24 ± 0.01 | 0.17 ± 0.01 | 0.21 ± 0.03 | 0.020 | 0.476 | 0.709 |
Data are presented as mean ± SEM (n = 5–6 rats per group).
*
P < 0.05 vs respective St diet group and
‡
P< 0.05 between St diet groups.
ALT, alanine transaminase; AST, aspartate transaminase.