Table 3.
Amino acid, acylcarnitine, succinylacetone, and hexacosanoyl lysophosphatidylcholine quantitation in anonymous residual newborn screening specimens (N = 151).
| Method including C26:0-LPC |
Region IV Stork (R4S) Data |
|||
|---|---|---|---|---|
| Analyte | Median, μM | Mean,| M | 95% C.I., μMa | Normal population 50th % |
| Phe | 60.8 | 63.0 | 32.0-94.0 | 49 |
| Leu | 75.0 | 79.4 | 29.4-129.4 | 127 |
| Met | 12.4 | 13.3 | 4.9-21.8 | 20 |
| Tyr | 83.9 | 89.0 | 30.8-147.2 | 83 |
| Val | 103.3 | 109.2 | 51.9-166.4 | 108 |
| Cit | 12.5 | 12.7 | 7.0-18.4 | 12.2 |
| Arg | 9.8 | 11.6 | 0.0-24.9 | 8.5 |
| Ala | 237.2 | 246.8 | 108.0-385.6 | 223 |
| SUAC | 0.9 | 0.9 | 0.6-1.1 | 0.6 |
| C0 | 17.1 | 18.4 | 5.7-31.1 | 22 |
| C2 | 15.7 | 15.8 | 4.2-27.4 | 21 |
| C3 | 1.5 | 1.6 | 0.3-3.0 | 1.7 |
| C4 | 0.1 | 0.2 | 0.0-0.5 | 0.2 |
| C3DC + C4OH | 0.2 | 0.1 | 0.0-0.2 | 0.1 |
| C5 | 0.1 | 0.1 | 0.0-0.3 | 0.1 |
| C5OH | 0.3 | 0.3 | 0.1-0.5 | 0.2 |
| C5DC | 0.2 | 0.2 | 0.0-0.3 | 0.1 |
| C6 | 0.1 | 0.1 | 0.0-0.1 | 0.1 |
| C8 | 0.1 | 0.1 | 0.0-0.2 | 0.1 |
| C10 | 0.1 | 0.2 | 0.0-0.3 | 0.1 |
| C12 | 0.1 | 0.1 | 0.0-0.2 | 0.1 |
| C14 | 0.2 | 0.2 | 0.1-0.3 | 0.2 |
| C16 | 2.4 | 2.5 | 1.0-4.1 | 2.7 |
| C16OH | 0.0 | 0.04 | 0.0-0.1 | 0.02 |
| C18 | 0.9 | 0.9 | 0.4-1.4 | 0.8 |
| C18OH | 0.03 | 0.04 | 0.0-0.1 | 0.01 |
| C26:0-LPC | 0.4 | 0.4 | 0.2-0.6 | NA |
a
The 95% confidence interval is from (mean – 1.96 × standard deviation) to (mean + 1.96 × standard deviation).