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. 2016 May;23(5):238–248. doi: 10.1101/lm.040923.115

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© 2016 Novitskaya et al.; Published by Cold Spring Harbor Laboratory Press

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Figure 4. — Post-learning ripple-triggered LC activation causes a reference memory deficit. Bars represent the group means on the last day of training for the number of rewards retrieved (A), performance accuracy (B), and trial time (C). Note significant learning deficit was present exclusively in the RT-HFS group. (*) P < 0.05, (**) P < 0.01, and (***) P < 0.001 compared with nonstimulated control (Dunnett's test). (NS) nonstimulated control, (RT-LFS) ripple-triggered low-frequency LC stimulation, (RT-HFS) ripple-triggered high-frequency LC stimulation, (RD-HFS) random high-frequency LC stimulation.