Fig 4. NK cell depletion in E. muris-primed mice decreases expansion of memory T cells.

Splenocytes from different groups of mice were stimulated with E. muris antigens and the frequency of memory cells was determined by flow cytometry. Lower percentages (A) and absolute numbers (B) of effector/effector memory (Em) (CD44^high CD62L^low), but not central memory (Cm) (CD44^high CD62L^high), CD4⁺ T cells in the spleens of NK^-/-E. muris compared with those found in NK^+/+E. muris or naïve mice infected with IOE on day 28 post-infection. ** indicate P < 0.01. Data are presented as the means ± SD of four mice per group from two independent experiments. ** indicates P <0.01.